Endocrine Abstracts

Introduction: Obesity is associated with a plethora of metabolic and physiological side effects. Excess adiposity is associated with raised intracranial pressure (ICP) in obesity, where raised ICP sequalae include headache and visual decline in humans. We aimed to assess the effects of diet induced obesity (DIO) on ICP and related neuroophthalmological outcomes of headache behavior and retinal anatomy in rats.Methods: Female Sprague-Dawley rats received ...

Background: Current therapies for reducing raised intracranial pressure (ICP) in conditions such as idiopathic intracranial hypertension have limited efficacy and tolerability. As such, there is a pressing need to identify novel drugs. Glucagon-like peptide-1 receptor (GLP-1R) agonists are used to treat diabetes and promote weight loss but have also been shown to affect fluid homeostasis in the kidney. Here, we investigate whether exendin-4, a GLP-1R agonist, is able to modula...

Background: Current therapies for reducing raised intracranial pressure (ICP) in conditions such as idiopathic intracranial hypertension have limited efficacy and tolerability. As such, there is a pressing need to identify novel drugs. Glucagon-like peptide-1 receptor (GLP-1R) agonists are used to treat diabetes and promote weight loss but have also been shown to affect fluid homeostasis in the kidney. Here, we investigate whether exendin-4, a GLP-1R agonist, is able to modula...